The 3rd International Conference on Main Group Synthesis and Catalysis (ICMGSC-2027) will be organized at the Indian Institute of Science Education and Research (IISER Thiruvananthapuram) from 19-22 May 2027. It aims to bring together practicing main group chemists around the globe fostering discussions on topical areas of interest in the field. The conference will feature 40 talks, poster presentations, and networking opportunities. This third edition is organised at the backdrop of the huge success of the first and the second editions which immensely benefited the main group chemistry community.